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Indomethacin major in general, nsaid therapy can decrease the clearance of methotrexate, resulting in elevated and prolonged serum methotrexate levels.

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Nauseavomitingstomach paindrowsinessor dizziness may occurIf any of these effects persist or worsentell your doctor or pharmacist promptly.

DisclaimerOur goal is to provide you with the most relevant and current informationHoweverbecause drugs interact differently in each personwe can not guarantee that this information includes all possible interactionsThis information is not a substitute for medical adviceAlways speak with your healthcare provider about possible interactions with all prescription drugsvitaminsherbs and supplementsand over-the-counter drugs that you are taking.

Methotrexate must not be used during pregnancyIt may harm an unborn babyIt is important to prevent pregnancy during and after treatment with methotrexateThereforemales and females must use reliable forms of birth controlsuch as condomsbirth control pillsduring treatmentMales should continue to use birth control for at least 3 months after the end of treatmentFemales should continue to use birth control for at least 1 menstrual cycle after the end of treatmentIf you become pregnant or think you may be pregnanttell your doctor right away.

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ibuprofen major in general, nsaid therapy can decrease the clearance of methotrexate, resulting in elevated and prolonged serum methotrexate levels.

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